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31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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The β-lactoglobulin: β-carotene enrichment vector of food

Food supplementation is one strategy for overcoming vitamin A deficiency in developing countries. Our objective was to study the involvement of β-lactoglobulin (β-Lg) bovine milk, potential carrier of retinoid in the absorption of vitamin A.

In vivo experiments were conducted by feeding mice with retinol or β-carotene associated either to the β-Lg either or to oil-in-water emulsions, with subsequent determination of the content of vitamin A in the intestinal mucosa or the plasma. Caco-2 cells were then used to study the mechanisms of absorption of vitamin A when released by the β-Lg or mixed micelles. We have shown that the β-Lg was as effective as the emulsion to promote the absorption of β-carotene, but not retinol in mice. Similar results were obtained in vitro. Interestingly, an inhibitor of class B type I "Scavenger Receptor"  decreased significantly the absorption of micellar β-carotene , but not that of β-carotene linked to β-Lg. The β-Lg would be a good vector for supplementation of food in β-carotene.


Vitamine A as rétinol configuration

See also


A. Mensi ; P. Borel ; A. Goncalves ; M. Nowicki ; B. Gleize ; S. Roi ; J.-M. Chobert ; T. Haertlé ; E. Reboul. Beta-lactoglobulin as compared to micelles and emulsion to promote intestinal absorption of vitamin A : studies in mice and in Caco-2 cells. J. Agric. Food. Chem., 2014, 62, 5916-5924.

A. Mensi ; Y. Choiset ; H. Rabesona ; T. Haertlé ; P. Borel ; J.-M. Chobert. Interactions of β-lactoglobulin variants A and B with vitamin A. Competitive binding of retinoids and carotenoids. J. Agric. Food Chem. 2013, 61, 4114-4119.

A. Mensi ; Y. Choiset ; T. Haertlé ; P. Borel ; J.-M. Chobert. Interlocking of β-carotene in beta-lactoglobulin aggregates produced under high pressure. In vitro gastro-duodenal digestion and the release of β-carotene by aggregates. Food Chem. 2013, 139, 253-260.