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Dernière mise à jour : Mai 2018

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Stimuli-responsive alginate microgels for the controlled delivery of actives and stabilization of interfaces

The stimuli-responsive or smart polymers are able to respond to external stress by a conformational change. The polymer swells or shrinks depending on the external stimulus (temperature, pH, salt concentration, ...). It will be the same when the polymer is cross-linked to form a hydrogel.

Hydrogels from synthetic polymer such as poly (N-isopropylacrylamide) (PNIPAAm) or from copolymers such as ethylene oxide and propylene (PEPO) is responsive toward pH and / or temperature, two key parameters in physiology. The potentials to biomedical and pharmaceutical applications are numerous especially in the capabilities of stimuli-responsive hydrogels to release actives on request or to change their shape depending on the external stimulus. Furthermore, the efficiency of the stimuli-responsive hydrogel will be bigger as this one will be small-sized. No study to date has been conducted on stimuli-responsive hydrogels based on biopolymers. Biopolymers from renewable resources indeed have a high affinity for water, are weakly toxic, and can be cross-linked by soft way without the addition of chemical agent. They therefore have large advantages for biomedical applications. In this context, we developed jointly a chemical method allowing the medication of a polymer of marine origin, alginate, to make it stimuli-responsive and a microfluidic method to produce stimuli-responsive alginate microgels of size perfectly controlled.

Partnerships :

UMR 6270 CNRS-Université de Rouen, Laboratoire Polymères, Biopolymères, Surfaces

Laboratoires Brothier, Fontevraud L’abbaye

Plate-forme BIBS, INRA Nantes-Angers

IMN, Nantes

References :

- C. Karakasyan, J. Mathos, S. Lack, J. Davy, M. Marquis, D. Renard (2015) Microfluidics-assisted generation of stimuli-responsive hydrogels based on alginates incorporated with thermo-responsive and amphiphilic polymers as novel biomaterials. Colloids and Surfaces B, 135, 619-629.