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Dernière mise à jour : Mai 2018

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Food allergy aggravates asthma in a mice model of atopic march

Les allergènes alimentaires
This work showed that the induction of wheat gluten food allergy aggravated the symptoms of subsequent induced mite asthma in mice. Moreover, this effect seems to be mediated by specific receptors that allow the migration of immune cells.

Allergies are constantly increasing in most developed countries. In addition, there is a clinical trend characteristic of allergic diseases over the lifespan, from food and skin allergies to respiratory allergies such as asthma. The purpose of this work was to understand the mechanisms involved in this evolution.

A mouse model mimicking this particular evolution has been developed. Mice subjected to the dual allergy protocol (food and respiratory) have worsened asthma symptoms. Indeed, food allergy seems to have an impact on lung function as well as on the inflammatory response. In addition, the role of a specific receptor (CCR9) for lymphocyte cell migration to the intestine was analyzed. The worsening of pulmonary inflammation thus seems to be dependent on the expression of CCR9 by T cells.


This work was carried out as part of a Thesis project under the supervision of A. Magnan, G. Bouchaud and S. Brouard in partnership with UMR INSERM 1087 - CNRS UMR 6291 (Nantes).


Castan L., Magnan A., & Bouchaud G. (2017). Chemokine receptors in allergic diseases. Allergy, 72(5), 682-690.

Castan L, Cheminant M-A, Colas L, Brouard S, Magnan A, Bouchaud G. (2018). Food allergen-sensitized CCR9+ lymphocytes enhance airways allergic inflammation in mice. Allergy. 73:1505–1514.