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Dernière mise à jour : Mai 2018

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Starch materials for biomedical implants

 shape memory amidon stent
© INRA, Nathalie Mansion
Natural polymers can meet the need to develop biocompatible and bioresorbable materials for the production of biomedical implants.

We studied in vitro and in vivo different starch materials. The best results in terms of aging resistance and biocompatibility were obtained on a plastic potato starch with glycerol.

This work was done in collaboration with the Cardiovascular Bioengineering Laboratory for therapy and medical imaging from INSERM in Paris and surgeons in hospitals of Lyon and Toulon. They were funded by the ANR in the framework of the project "Irmas" and by the  Pays de Loire region with the PhD fellowship of Diego Velasquez.

References :

BEILVERT A., CHAUBET F., CHAUNIER L., GUILOIS S., PAVON-DJAVID G., LETOURNEUR D., MEDDAHI-PELLÉ A., LOURDIN D. Shape-memory starch for resorbable biomedical devices Carbohydrate Polymers, 99, 242– 248, 2014

BEILVERT A., FAURE F., MEDDAHI-PELLÉ A., CHAUNIER L., GUILOIS S., CHAUBET F., LOURDIN D., BIZEAU A. A resorbable shape-memory starch-based stent for the treatment of salivary ducts under sialendoscopic-surgery, The Laryngoscope, 124, Issue 4, 875–881, 2014

VELASQUEZ D., PAVON-DJAVID G., CHAUNIER L., MEDDAHI-PELLÉ A., LOURDIN D. Effect of Crystallinity, Plasticizer Content and Botanical Origin of Starch-Based Materials on Mechanical Properties and In Vivo Tissue Integration, Carbohydrate Polymers, 124, 180-187, 2015