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Allergies are constantly increasing in most developed countries. In addition, there is a clinical trend characteristic of allergic diseases over the lifespan, from food and skin allergies to respiratory allergies such as asthma. The purpose of this work was to understand the mechanisms involved in this evolution.

A mouse model mimicking this particular evolution has been developed. Mice subjected to the dual allergy protocol (food and respiratory) have worsened asthma symptoms. Indeed, food allergy seems to have an impact on lung function as well as on the inflammatory response. In addition, the role of a specific receptor (CCR9) for lymphocyte cell migration to the intestine was analyzed. The worsening of pulmonary inflammation thus seems to be dependent on the expression of CCR9 by T cells.

Partnership

This work was carried out as part of a Thesis project under the supervision of A. Magnan, G. Bouchaud and S. Brouard in partnership with UMR INSERM 1087 - CNRS UMR 6291 (Nantes).

Publications

Castan L., Magnan A., & Bouchaud G. (2017). Chemokine receptors in allergic diseases. Allergy, 72(5), 682-690. http://doi.org/10.1111/all.13089

Castan L, Cheminant M-A, Colas L, Brouard S, Magnan A, Bouchaud G. (2018). Food allergen-sensitized CCR9+ lymphocytes enhance airways allergic inflammation in mice. Allergy. 73:1505–1514. https://doi.org/10.1111/all.13386