Know more

MiBioGate, winner of the call for proposals "scientific dynamics" launched by the Pays de la Loire region, it brings together 11 regional and interregional partners for 5 years.
The purpose of this consortium is to structure a research network specialized in the dysfunction of the biological barriers of different organs in chronic pathologies.

The MiBioGate project aims is to characterize the molecular and phenotypic alterations of epithelial barriers and  cutaneous, intestinal and pulmonary microbiotes during the following pathologies:

• Allergies / Asthma
• Liver diseases (Non-alcoholic Fatty Liver Disease)
• Chronic inflammatory bowel diseases (Crohn's disease and Hemorrhagic Rectocolitis)
• Diseases of the intestinal-brain axis (neurodevelopmental, neurodegenerative and psychiatric)

The objective is to identify potential therapeutic which act on microbiota (prebiotic, probiotic) or barrier mediators (junction proteins, inflammatory mediators, danger receptors).

The Allergy team is involved in the study of barrier dysfunctions during food and respiratory allergies. Researchers from the team supervise theses in co-supervision with various academic laboratories in the Pays de la Loire region:

Barrier dysfunction in respiratory/asthma allergies
Supervisor: Pr Antoine Magnan (UMR1087 IT) / Dr Grégory Bouchaud (UMR1268 BIA)

Barrier dysfunction in IDB (Chronic Inflammatory Bowel Diseases) _ Amelie Le
Supervisor: Dr Malvyne Rolli-Derkinderen (UMR1235 TENS) / Dr Marie Bodinier (UMR1268 BIA)