Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Oniris

Home page

Bluetongue virus serotype 8 infection and performance in dairy cattle herds

Decreases in reproductive performance and milk production associated with infection of a dairy cattle herd with Bluetongue virus serotype 8 (BTV-8) are significant and last for several weeks. Marked degradations in performance have also been found in herds located in infected areas but not reported by the surveillance system. This shows that the impact of the epizootic was much greater than the effects described in the notified herds. A secondary effect of vaccination on fertility has been identified but is very limited compared to the effects of the infection.

National and/or international context/ issues/ problematic

Following the emergence of BTV-8 in Northern Europe in 2006, vaccination was introduced in France to limit the spread of the virus. No ex ante evaluation of the benefit/risk ratio of vaccination has been performed. This type of assessment requires knowledge, in particular about losses caused by the disease and potential side effects of vaccination on cattle performance.

Exposure to BTV-8 on performance leads to a degradation of the zootechnical performance of the animals: decreases in reproductive performance and milk production. However, the associated losses have not been precisely quantified.


BTV-8 infection in a previously naïve cattle population is associated with reduced milk production performance and fertility and an increased risk of abortion. These effects are important in terms of magnitude and duration (3% decrease in milk production over a 6-month period and 12% decrease in fertility on average in infected herds where clinical signs have been observed and reported).

Decreases in fertility have also been detected in herds not reported infected by the surveillance system and located in areas of the epizootic. This effect corresponds to 60% of the effect quantified in the notified infected herds. This effect could be estimated using an innovative spatial statistical method, kriging, which made it possible to predict a probable date of infection for these herds. Considering the effects at the scale of a region, the cumulative losses of infection are therefore significant. Decreases in animal performance also provide additional information from disease surveillance on the likely date of virus introduction into the herds. Indeed, declines in performance are detectable on average a few weeks before signs are detected. They are also very early in herds where the disease was detected late. This indicates that virus circulation in the herds is generally earlier (up to 10 weeks) than the detection of infection by the farmers.

Finally, vaccination against BTV-8 with an inactivated vaccine is associated with a very slight decrease in fertility (4%). The major performance losses associated with exposure, compared to the very limited side effects of vaccination, seem to justify the strategies that have been implemented in the field.

Perspectives/eventual impact

Quantification of the performance effects of BTV-8 and vaccination against BTV-8 are useful (i) for the economic evaluation of the consequences of this epizootic and (ii) for the evaluation of control strategies against BTV-8 (e.g. evaluation of the benefit-risk ratio of vaccination). The evaluation of these strategies a posteriori provides valuable elements of decision support, which can be mobilised in the event of a re-emergence of the virus.

In view of the performance variations revealed in infected herds, it would be interesting to assess whether monitoring performance variations can be integrated as an alert system within the framework of syndromic surveillance of the emergence of epizootic diseases (study in progress within the UMR). This requires prior study of the capacity of such a system to rapidly detect deviations from expected performance, without having a priori information on the occurrence and timing of herd exposure in a region.


Union Bretonne des Groupements de Défense Sanitaire, Direction Générale de l'Alimentation (Brittany Union of Health Defence Groups)


Communication of the results in working groups with stakeholders in health management and contribution to the drafting of documents for livestock advisors and breeders :

  • Special file Catarrhal Ovine Fever. Sanitary echo. The newsletter of the Breton GDS. Dec. 2010
  • Vaccination against CFO: what impact on the fertility of cattle herds? The Institute of Animal Husbandry. Collection l'essentiel. June 2012



  • Nusinovici S, Seegers H, Joly A, Beaudeau F, Fourichon C. 2011. A side effect of decreased fertility associated with vaccination against bluetongue virus serotype 8 in Holstein dairy cows. Prev. Vet. Med. 101:42-50
  • Nusinovici, S., H. Seegers, A. Joly, F. Beaudeau, and C. Fourichon. 2012a. Quantification and at-risk period of decreased fertility associated with exposure to Bluetongue virus serotype 8 in naïve dairy herds. Journal of dairy science 95:3008-20
  • Nusinovici, S., H. Seegers, A. Joly, F. Beaudeau, and C. Fourichon. 2012b. Increase in the occurrence of abortions associated with exposure to Bluetongue virus serotype 8 in naïve dairy herds. In press. Theriogenology 78:1140-51
  • Nusinovici S, Souty C, Seegers H, Beaudeau F, Fourichon C. Decrease in milk yield associated with exposure to Bluetongue virus serotype 8 in cattle herds. En révision (Journal of dairy science)
  • Nusinovici S, Seegers H, Souty C, Monestiez P, Joly A, Beaudeau F, Fourichon C. Infection par le virus Bluetongue sérotype 8 et performances dans les troupeaux bovins laitiers. Bulletin épidémiologique, santé animale et alimentation n°51 p 13
  • Nusinovici S. Infection par le virus Bluetongue sérotype 8 et performances dans les troupeaux bovins laitiers. Thèse d’université soutenue le 16 décembre 2011, Oniris, Nantes

See also

Simon Nusinovici INRA, UMR1300 BioEpAR, CS 40706, F-44307 Nantes

            simon (point) nusinovici (at) oniris-nantes (point) fr

Christine Fourichon Oniris, UMR1300 BioEpAR, CS 40706, F-44307 Nantes

            christine (point) fourichon (at) oniris-nantes (point) fr