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One possible way to reduce the use of antibiotics in veterinary medicine and their impact on the emergence of resistance is the use of treatment with a reduced dose. We have validated experimentally and under animal husbandry conditions the efficacy of treating infectious bovine bronchopneumonia with a reduced dose of marbofloxacin. In order to obtain a favourable effect on antibiotic consumption, it remains necessary to develop methods for early detection of sick animals in order to target those for whom treatment is necessary. Adapting antibiotic doses requires the deployment of precision veterinary medicine, combining diagnostic tools, animal monitoring, and adjusted drug protocols.

Bibliography :

Lhermie G., Toutain P.L., El Garch F., Bousquet-Mélou A., Assié S. (2017) “Implementing Precision Antimicrobial Therapy for the Treatment of Bovine Respiratory Disease: Current Limitations and Perspectives.” Front Vet Sci. 2017 Aug 29; 4: 143. DOI: 10.3389/fvets.2017.00143.

Lhermie G., Gröhn Y.T., Raboisson D. (2017) “Addressing Antimicrobial Resistance: An Overview of Priority Actions to Prevent Suboptimal Antimicrobial Use in Food-Animal Production”. Front Microbiol. 2017 Jan 6; 7: 2114.
DOI: 10.3389/fmicb.2016.02114.

Lhermie G., Dupouy V., El Garch F., Ravinet N., Toutain P.L., Bousquet-Mélou A., Seegers H., Assié S. (2017) “Impact of Low and High Doses of Marbofloxacin on the Selection of Resistant Enterobacteriaceae in the Commensal Gut Flora of Young Cattle: Discussion of Data from 2 Study Populations.” Foodborne Pathog Dis. 2017 Mar; 14(3): 152-159. DOI: 10.1089/fpd.2016.2176.

Link to the national INRAE blog : http://2025.inra.fr/3perf/Billets/SA-Faits-marquants-2017-contribution-a-3Perf-2-traitement-precoce-des-bronchopneumonies-bovines