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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Bertho Nicolas

Team ImmunoCare

Bertho Nicolas
© NB

INRAE Research Fellow
UMR 1300 BIOEPAR

Adress:
 Oniris site de la Chantrerie, CS40706, 44307 Nantes, France
 team ImmunoCare, building G5 2nd floor

Email: nicolas (point) bertho (at) oniris-nantes (point) fr
Tel: 02 72 20 29 69

Nicolas Bertho did his PhD in Immunology on the apoptosis of human dendritic cells, in the Laboratory of Hematology of the Faculty of Medicine of Rennes 1. His thesis defended in 2000, he did a 2-year postdoctoral training at Harvard Medical Scool (Boston, USA), in the laboratory of Hidde Ploegh, where he worked on dendritic cell/T-lymphocyte interactions in mice. In early 2003, he continued his career with a post-doctoral fellowship at the Centre Régional de Lutte Contre le Cancer in Rennes, France, where he studied the ability of human dendritic cells to migrate to the lymph node. At the end of 2004, Nicolas Bertho joined Jean Davoust's immunology team at Généthon (Evry), where he explored tolerance induction in mouse models.

In 2005, he joined INRA at the Laboratory of Virology and Molecular Immunology (VIM) in Jouy en Josas, in Isabelle Schwartz-Cornil's Immunology team. He then focused on the phenotypic and functional description of different populations of porcine dendritic cells and skin and lung macrophages in order to develop protocols for skin vaccination against influenza and anti-SDRP. He is also interested in the respiratory immunopathologies induced by these two diseases and is developing in parallel the pig as a biomedical model.

Author of numerous publications in international peer-reviewed journals, he participates in national (ANR, INCA) and European (H2020, ERANET, NADIR) projects.

Today at BIOEPAR, while maintaining a focus on influenza and SDRP infections, he develops applied and cognitive research on the pathogenic impact of respiratory co-infections and the control of these diseases in pig farms.

Research Themes

  • Pork
  • Infectiology
Links

http://www.researchgate.net/profile/Nicolas Bertho

Publications
  • Saade G., Deblanc C., Bougon J., Marois-Crehan C., Fablet C., Auray G., Belloc C., Leblanc-Maridor M., Gagnon C.A., Zhu J., Gottschalk M., Summerfield A., Simon G., Bertho N., Meurens F. 2020. Coinfections and their molecular consequences in the porcine respiratory tract. Veterinary Research, 51(1):80 [IF19=3.357] DOI: 10.1186/s13567-020-00807-8.
  • Bernelin-Cottet C., Urien C., Fretaud M., Langevin C., Trus I., Jouneau L., Blanc F., Leplat J.-J., Barc C., Boulesteix O., Riou M., Dysart M., Mahé S., Studsrub E., Nauwynck H., Bertho N., Bourry O., Schwartz-Cornil I. 2019. A DNA Prime Immuno-Potentiates a Modified Live Vaccine against the Porcine Reproductive and Respiratory Syndrome Virus but Does Not Improve Heterologous Protection. Viruses, 11(6):576 DOI: 10.3390/v11060576.
  • Bernelin-Cottet C., Urien C., McCaffrey J., Collins D., Donadei A., McDaid D., Jakob V., Barnier-Quer C., Collin N., Bouguyon E., Bordet E., Barc C., Boulesteix O., Leplat J.-J., Blanc F., Contreras V., Bertho N., Moore A. C., Schwartz-Cornil I. 2019. Electroporation of a nanoparticle-associated DNA vaccine induces higher inflammation and immunity compared to its delivery with microneedle patches in pigs. Journal of Controlled Release, 308:14-28 [IF19=7.727] DOI: 10.1016/j.jconrel.2019.06.041.
  • Bernelin-Cottet C., Urien C., Stubsrud E., Jakob V., Bouguyon E., Bordet E., Barc C., Boulesteix O., Contreras V., Barnier-Quer C., Collin N., Trus I., Nauwynck H., Bertho N., Schwartz-Cornil I. 2019. A DNA-Modified Live Vaccine Prime–Boost Strategy Broadens the T-Cell Response and Enhances the Antibody Response against the Porcine Reproductive and Respiratory Syndrome Virus. Viruses, 11(6) :551 DOI: 10.3390/v11060551.
  • Bordet E., Frétaud M., Crisci E., Bouguyon E., Rault S., Pezant J., Pleau A., Renson P., Giuffra E., Larcher T., Bourge M., Bourry O., Boulesteix O., Langevin C., Schwartz-Cornil I., Bertho N. 2019. Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus. Frontiers in Immunology, 10(953) [IF19=5.085] DOI: 10.3389/fimmu.2019.00953.
  • Dhorne-Pollet, S., Crisci, E., Mach, N., Renson, P., Jaffrézic, F., Marot, G., Maroilley, T., Moroldo, M., Lecardonnel, J., Blanc, F., Bertho, N., Bourry, O., and Giuffra, E. 2019. The miRNA-targeted transcriptome of porcine alveolar macrophages upon infection with Porcine Reproductive and Respiratory Syndrome Virus. Scientific Reports 9(1):3160 [IF19=3.998] DOI: 10.1038/s41598-019-39220-3.
  • Bordet E, Maisonnasse P, Renson P, Bouguyon E, Crisci E, Tiret M, Descamps D, Bernelin-Cottet C, Urien C, Lefèvre F, Jouneau L, Bourry O, Leplat JJ, Schwartz-Cornil I, Bertho N. 2018. Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus. Scientific Reports 8(1):10172 [IF19=3.998] DOI: 10.1038/s41598-018-28234-y.
  • Maisonnasse P, Bouguyon E, Piton G, Ezquerra A, Urien C, Deloizy C, Bourge M, Leplat JJ, Simon G, Chevalier C, Vincent-Naulleau S, Crisci E, Montoya M, Schwartz-Cornil I, Bertho N. 2016. The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model. Mucosal Immunology 9(4):835-49 [IF19=6.726] DOI: 10.1038/mi.2015.105.
  • Maisonnasse P, Bordet E, Bouguyon E, Bertho N. 2017. Broncho Alveolar Dendritic Cells and Macrophages Are Highly Similar to Their Interstitial Counterparts. PLoS One. 11(12):e0167315 [IF19=2.740] DOI: 10.1371/journal.pone.0171852.
  • Bernelin-Cottet C, Deloizy C, Stanek O, Barc C, Bouguyon E, Urien C, Boulesteix O, Pezant J, Richard CA, Moudjou M, Da Costa B, Jouneau L, Chevalier C, Leclerc C, Sebo P, Bertho N, Schwartz-Cornil I. 2016. A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies. Frontiers in Immunology 7:641 [IF19=5.085] DOI: 10.3389/fimmu.2016.00641.
  • Marquet F, Vu Manh TP, Maisonnasse P, Elhmouzi-Younes J, Urien C, Bouguyon E, Jouneau L, Bourge M, Simon G, Ezquerra A, Lecardonnel J, Bonneau M, Dalod M, Schwartz-Cornil I, Bertho N. 2014. Pig skin includes dendritic cell subsets transcriptomically related to human CD1a and CD14 dendritic cells presenting different migrating behaviors and T cell activation capacities. Journal of Immunology 193(12):5883-5893 [IF19=4.886] DOI: 10.4049/jimmunol.1303150.

 

See also

Nicolas Bertho's publications in ProdINRA