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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Laurence Malandrin

Team TiBoDi

Laurence Malandrin
© LM

INRAE Research Fellow

 Oniris site de la Chantrerie, CS40706, 44307 Nantes, France
 team TiBoDi, building G2 2nd floor

Email: laurence (point) malandrin (at) oniris-nantes (point) fr
Tel: 02 40 68 78 57

Research Department

Animal Health

  • 2011: Habilitation to conduct research
  • 2000 to the present: INRA Research Fellow
  • Postdoctoral fellowship 2000. "Quorum sensing and triggering virulence factors in E. coli EPEC". University of Nottingham, England
  • Post-doctorate 1997-2000. "The cell cycle of hyperthermophilic Archaea." Biomedical Centre, University of Uppsala, Sweden
  • Post-doctorate 1996 INA-PG. "Pathogenicity factors in Erwinia amylovora."
  • Doctorate in Microbiology 1992-1995. Carried out at the INRA of Angers "Surface proteins of Pseudomonas syringae (sensu lato). Description, variability and taxonomic application". Thesis of the University of Angers.
  • Marie Curie European Mobility Grant 1992. Federal Biological Research Centre for Agriculture and Forestry, Brunswick, Germany
  • DEA 1991. "Science and Techniques of Plant and Food Production". University of Nantes, France
Thèmes de recherche

Diseases due to Protozoa and tick-borne intraerythocytic protozoa and bacteria in herbivores :

  • characterization and genetic diversity of species belonging to the genera Babesia, Theileria, Anaplasma,
  • vertebrate host specificities (host range and cellular analysis of erythrocyte interactions)
  • tick vector competence (vector identification and vector transmission).


  • Charrier, N. P., Hervet, C., Bonsergent, C., Charrier, M., Malandrin, L., Kaufmann, B., and Gippet, J. M. W. 2020. Invasive in the North: new latitudinal record for Argentine ants in Europe. Insectes Sociaux 67(2):331-335 [IF19=1.418] DOI: 10.1007/s00040-020-00762-9.
  • Paleau A., Candolfi E., Souply L., De Briel D., Delarbre J. M., Lipsker D., Jouglin M., Malandrin L., Hansmann Y., Martinot M. 2019. Human babesiosis in Alsace. Médecine et Maladies Infectieuses, 50(6):486-491 [IF19=1.782] DOI: 10.1016/j.medmal.2019.08.007.
  • Jouglin, M., Blanc, B., de la Cotte, N., Bastian, S., Ortiz, K., and Malandrin, L. 2019. First detection and molecular identification of the zoonotic Anaplasma capra in deer in France. PLoS ONE 14(7):e0219184 [IF19=2.740] DOI: 10.1371/journal.pone.0219184.
  • Jalovecka M., Hajdusek O., Sojka D., Kopacek P., Malandrin L. 2018. The Complexity of Piroplasms Life Cycles. Frontiers in Cellular and Infection Microbiology, 8(248). [IF19=4.123] DOI: 10.3389/fcimb.2018.00248.
  • Jouglin M., De la Cotte N., Bonsergent C., Bastian S., Malandrin L. 2018. La Babésiose humaine : bilan de 10 ans d’analyses. Médecine et Maladies Infectieuses, 48(4, Supplement):S112-S113 [IF19=1.782] DOI: 10.1016/j.medmal.2018.04.284.
  • Sertour N., Cotté V., Garnier M., Malandrin L., Ferquel E., Choumet V. 2018. Infection Kinetics and Tropism of Borrelia burgdorferi sensu lato in Mouse After Natural (via Ticks) or Artificial (Needle) Infection Depends on the Bacterial Strain. Frontiers in Microbiology, 9(1722) [IF19=4.235] DOI: 10.3389/fmicb.2018.01722.
  • Jouglin M., Chagneau S., Faille F., Verheyden H., Bastian S., Malandrin L. 2017. Detecting and characterizing mixed infections with genetic variants of Anaplasma phagocytophilum in roe deer (Capreolus capreolus) by developing an ankA cluster-specific nested PCR. Parasites & Vectors, 10(1):377 [IF19=2.824] DOI: 10.1186/s13071-017-2316-0.
  • Jouglin M., Perez G., Butet A., Malandrin L., Bastian S. 2017. Low prevalence of zoonotic Babesia in small mammals and Ixodes ricinus in Western France. Veterinary Parasitology, 238:58-60 [IF19=2.157] DOI:        10.1016/j.vetpar.2017.03.020.
  • Jalovecka M., Bonsergent C., Hajdusek O., Kopacek P., Malandrin L. 2016. Stimulation and quantification of Babesia divergens gametocytogenesis. Parasites & Vectors, 9(1):439. [IF19=2.824] DOI: 10.1186%2Fs13071-016-1731-y.
  • Niu Q., Bonsergent C., Rogniaux H., Guan G., Malandrin L., Moreau E. 2016. RAP-1a is the main rhoptry-associated-protein-1 (RAP-1) recognized during infection with Babesia sp. BQ1 (Lintan) (B. motasi-like phylogenetic group), a pathogen of sheep in China. Veterinary Parasitology, 232:48-57. [IF19=2.157] DOI: 10.1016/j.vetpar.2016.11.013.
  • Lempereur L., Shiels B., Heyman A., Moreau E., Saegerman C., Losson B., Malandrin L. 2015. A retrospective serological survey on human babesiosis in Belgium. Clinical Microbiology and Infection 21(1):96.e91-96.e97. [IF19=7.117] DOI: 10.1016/j.cmi.2014.07.004.
  • Moreau E., Bonsergent C., Al Dybiat I., Gonzalez L. M., Lobo C. A., Montero E., Malandrin L. 2015. Babesia divergens apical membrane antigen-1 (BdAMA-1): A poorly polymorphic protein that induces a weak and late immune response. Experimental Parasitology 155:40-45. [IF19=1.690] DOI: 10.1016/j.exppara.2015.04.024.
  • Niu Q., Marchand J., Yang C., Bonsergent C., Guan G., Yin H., Malandrin L. 2015. Rhoptry-Associated-Protein (RAP-1) genes in the sheep pathogen Babesia sp. Xinjiang: multiple copies differing by 3' end repeated sequences. Veterinary Parasitology 211(3-4):158-169. [IF19=2.157] DOI: 10.1016/j.vetpar.2015.04.030.
  • Cotté V., Sabatier L., Schnell G., Carmi-Leroy A., Rousselle J.-C., Arsène-Ploetze F., Malandrin L., Sertour N., Namane A., Ferquel E., Choumet V. 2014. Differential expression of Ixodes ricinus salivary gland proteins in the presence of the Borrelia burgdorferi sensu lato complex. Journal of Proteomics 96, 29-43 [IF19=3.509]. DOI: 10.1016/j.jprot.2013.10.033.
  • Jackson A.P., Otto T.D., Darby A., Ramaprasad A., Xia D., Echaide I.E., Farber M., Gahlot S., Gamble J., Gupta D., Gupta Y., Jackson L., Malandrin L., Malas T.B., Moussa E., Nair M., Reid A.J., Sanders M., Sharma J., Tracey A., Quail M.A., Weir W., Wastling J.M., Hall N., Willadsen P., Lingelbach K., Shiels B., Tait A., Berriman M., Allred D.R., Pain A. 2014. The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host–parasite interaction. Nucleic Acids Research 42(11):7113-7131 [IF19=11.501]. DOI: 10.1093/nar/gku322.
  • Jouglin M., Fernandez-de-Mera I., De la Cotte N., Ruiz-Fons F., Gortazar C., Moreau E., Bastian S., de la Fuente J., Malandrin L. 2014. Isolation and characterization of Babesia pecorum sp. nov. from farmed red deer (Cervus elaphus). Veterinary Research 45(1):78 [IF19=3.357]. DOI: 10.1186/s13567-014-0078-7.
  • Niu Q., Valentin C., Bonsergent C., Malandrin L. 2014. Strong conservation of rhoptry-associated-protein-1 (RAP-1) locus organization and sequence among Babesia isolates infecting sheep from China (Babesia motasi-like phylogenetic group). Infection Genetics and Evolution 28, 21-32 [IF19=2.773]. DOI: 10.1016/j.meegid.2014.08.028.
  • Becker C. A. M., Malandrin L., Larcher T., Chauvin A., Bischoff E., Bonnet S. I. 2013. Validation of BdCCp2 as a marker for Babesia divergens sexual stages in ticks. Experimental Parasitology 133(1):51-56 [IF19=1.690]. DOI: 10.1016/j.exppara.2012.10.007.
  • Niu Q., Bonsergent C., Guan G. Q., Yin H., Malandrin L. 2013. Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group). Veterinary Parasitology 198(1-2):24-38 [IF19=2.157]. DOI: 10.1016/j.vetpar.2013.08.025.
  • Agoulon A., Malandrin L., Lepigeon F., Vénisse M., Bonnet S., Becker C. A. M., Hoch T., Bastian S., Plantard O., Beaudeau F. 2012. A Vegetation Index qualifying pasture edges is related to Ixodes ricinus density and to Babesia divergens seroprevalence in dairy cattle herds. Veterinary Parasitology, 185(2-4):101-109 [IF19=2.157] DOI: 10.1016/j.vetpar.2011.10.022.
  • Bastian S., Jouglin M., Brisseau N., Malandrin L., Klegou G., L’Hostis M., Chauvin A. 2012. Antibody prevalence and molecular identification of Babesia spp. in roe deer in France. Journal of Wildlife Diseases 48(2):416-424 [IF19=1.187]. DOI: 10.7589/0090-3558-48.2.416.
  • Hoch T., Goebel J., Agoulon A., Malandrin L. 2012. Modelling bovine babesiosis: A tool to simulate scenarios for pathogen spread and to test control measures for the disease. Preventive Veterinary Medicine 106(2):136-142 [IF19=2.304] DOI: 10.1016/j.prevetmed.2012.01.018.
  • Sun Y., Jouglin M., Bastian S., Chauvin A., Malandrin L. 2011. Molecular cloning and genetic polymorphism of Babesia capreoli gene Bcp37/41, an ortholog of Babesia divergens merozoite surface antigen Bd37. Veterinary Parasitology 178(1-2):184-191 [IF19=2.157]. DOI: 10.1016/j.vetpar.2010.12.021.
  • Sun Y., Moreau E., Chauvin A., Malandrin L. 2011. The invasion process of bovine erythrocyte by Babesia divergens: knowledge from an in vitro assay. Veterinary Research 42:62 [IF19=3.357]. DOI: 10.1186/1297-9716-42-62.
  • Becker C.A.M., Malandrin L., Depoix D., David P.H., Chauvin A., Bischoff E., Bonnet S. 2010. Identification of three CCp genes in Babesia divergens: novel markers for sexual stages parasites. Molecular and Biochemical Parasitology 174(1):36-43 [IF19=1.571] DOI: 10.1016/j.molbiopara.2010.06.011.
  • Malandrin L., Jouglin M., Sun Y., Brisseau N., Chauvin A. 2010. Redescription of Babesia capreoli (Enigk and Friedhoff, 1962) from roe deer (Capreolus capreolus): Isolation, cultivation, host specificity, molecular characterisation and differentiation from Babesia divergens. International Journal for Parasitology 40(3):277-284 [IF19=2.783] DOI: 10.1016/j.ijpara.2009.08.008.
  • Becker C. A. M., Bouju-Albert A., Jouglin M., Chauvin A., Malandrin L. 2009. Natural Transmission of Zoonotic Babesia spp. by Ixodes ricinus Ticks. Emerging Infectious Diseases 15:320-322 [IF19=6.259] DOI: 10.3201/eid1502.081247.
  • Chauvin A., Moreau E., Bonnet S., Plantard O., Malandrin L. 2009. Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission. Veterinary Research 40:37 [IF19=3.357] DOI: 10.1051/vetres/2009020.
  • Malandrin L., Jouglin M., Moreau E., Chauvin A. 2009. Individual heterogeneity in erythrocyte susceptibility to Babesia divergens is a critical factor for the outcome of experimental spleen-intact sheep infections. Veterinary Research 40:25 [IF19=3.357] DOI: 10.1051/vetres/2009008.
  • Moreau E., Jouglin M., Chauvin A., Malandrin L. 2009. Babesia divergens experimental infection of spleen-intact sheep results in long-lasting parasitemia despite a strong humoral response: Preliminary results. Veterinary Parasitology 166:205-211 [IF19=2.157] DOI: 10.1016/j.vetpar.2009.08.021.
  • Lundgren M., Malandrin L., Eriksson S., Huber H., Bernander R. 2008. Cell Cycle Characteristics of Crenarchaeota: Unity among Diversity. Journal of Bacteriology 190:5362-5367 [IF19=3.004] DOI: 10.1128/JB.00330-08.
  • Bonnet S., Jouglin M., Malandrin L., Becker C. A. M., Agoulon A., L'Hostis M., Chauvin A. 2007. Transstadial and transovarial persistence of Babesia divergens DNA in Ixodes ricinus ticks fed on infected blood in a new skin-feeding technique. Parasitology 134:197-207 [IF19=2.783] DOI: 10.1017/S0031182006001545.


See also

Laurence Malandrin's publications in ProdINRA