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Last update: May 2021

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APPIFISH: Antibiotic resistance Pathogenicity Infectiology in fish

Understanding resistance in aquatic environments and improving the medical approach in aquaculture

APPIFISH: Antibiotic resistance Pathogenicity Infectiology in fish
The APPIFISH team conducts works to improve understanding of the pathogenic bacteria and for a better apprehension of the health of aquaculture organisms.

Context and Issues

  • Importance of bacterial infectious diseases in aquaculture
  • Ecoantibio 1 & 2 Plan: Willingness to reduce medicinal inputs by 25%


  • A better understanding of the genetic and phenotypic variability of isolated pathogenic bacteria in fish farms,
  • A better understanding of the persistence of the infectious agent in livestock by identifying potential reservoirs,
  • A better understanding of the immune interactions between the pathogen and its host.

The final objective is to better understand the control strategies of two bacteria Yersinia ruckeri and Flavobacterium psychrophilum by developing prophylactic means and limiting the use of antibiotic-type inputs.

Target species

Fish pathology bacteria

  • Yersinia ruckeri
  • Aeromonas spp.
  • Flavobacterium psychrophilum

Application fields

  • Aquaculture (rainbow trout)
  • Bacterial diseases of farming fishes
  • Antimicrobial-resistance
  • Bacterial genetic variability

Expertise and skills

  • Bacteriology
  • Physiopathology
  • Immunology
  • Epidemiology
  • Pharmacology

Current projects

  • Alter for fish (A2F): Efficacy and safety of alternative(s) to antibiotics for farmed fish (Ecoantibio 2 project: 2018 - 2020)
  • RESIST3A : Resistance - Antibiotics - Aquaculture - Alternatives - Integration of fish farms; Health context and antimicrobial resistance; Development of pilot approaches and Flavobacteriosis prevention