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This holistic approach allowed clear-cut differences in mature milk-lipidomic signature according to maternal diet but a similar protein, lactose and leptin content. The lower WD-milk content in total fat and triglycerides (TGs), particularly in TGs-with saturated medium-chain, and higher levels in both sphingolipid (SL) and TG species with unsaturated long-chain were associated to a specific offspring blood-lipidome with decreased levels in TGs-containing saturated fatty acid (FA). The sexual-dimorphism in the FA-distribution in TG (higher TGs-rich in oleic and linoleic acids, specifically in males) and SL species (increased levels in very long-chain ceramides, specifically in females) could be associated to the postnatal discrepancy we observed between males and females as a higher total body weight gain in females and an enhanced preference for fatty taste only in males, at weaning.

Publication:

Alexandre-Goubau M.C., David-Souchard A., Parnet P., Paille V. High caloric perinatal maternal diet impact breast milk metabotype and developmental offspring outcome, in a sex-specific manner. International Journal Molecular Science - Special Issue Bioactive Lipids and Lipidomics 2020, 21 (15), 5428; https://doi.org/10.3390/ijms21155428